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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) of greater than 27, provided that they also suffer from weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so that as an aid to stop smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie diet and exercise, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical exercise. Results from a medical trial that enrolled patients without diabetes established that patients had a typical weight loss of 4.1% rather than participants who have been given placebos) during a 12- month period, while another study involving patients with diabetes had a normal weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to shed weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with fat loss and the people who go through it you need to err to the side of caution and allow FDA do its job and demand some research be done so the public understands the side effects and risks of the medications before we drive them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on his or her medications.

Researchers found that participants taking this drug for any year, dropped excess weight within 4 weeks and have kept the extra weight off through the 56 weeks with the study. Contrave can be a combination from the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which are made up of multiple active ingredient, that might make them more effective and safer.

Combo-pilling could be the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular may be the fact that since right now there aren't any long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug can also raise blood pressure levels and heartbeat, and really should not be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartrate and must stop used in patients with uncontrolled high hypertension, as well as by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients having a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients to the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.


New UCLA study on smokers with mental, drug, and alcohol problems